677746-25-7
677746-25-7
Chemical Structure
K 01-162
Synonym(s): K162
- CAS No.: 677746-25-7
- Formula:C15H14BrN
- Molecular Weight:288.18
IUPAC Name: 7-bromo-N,N-dimethyl-9H-fluoren-2-amine
InChIKey: KABXKWWJTYSDTD-UHFFFAOYSA-N
SMILES: BrC1=CC(CC2=C3C=CC(N(C)C)=C2)=C3C=C1
Biological Activity: K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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K 01-162 | 98.0% | K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease. | ||||||||||||||||||||
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References
- [1]. Li J, et al. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16;100(4):1076-82. [Content Brief]
- [2]. Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct;31(10):1690-9. [Content Brief]
Keywords
