1. Neuronal Signaling
  2. Amyloid-β

K 01-162 (Synonyms: K162)

Cat. No.: HY-14533 Purity: 99.12%
Handling Instructions

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.

For research use only. We do not sell to patients.

K 01-162 Chemical Structure

K 01-162 Chemical Structure

CAS No. : 677746-25-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 571 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50) Target: Amyloid-β in vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2] in vivo:K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4701 mL 17.3503 mL 34.7005 mL
5 mM 0.6940 mL 3.4701 mL 6.9401 mL
10 mM 0.3470 mL 1.7350 mL 3.4701 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

288.18

Formula

C₁₅H₁₄BrN

CAS No.

677746-25-7

SMILES

BrC1=CC(CC2=C3C=CC(N(C)C)=C2)=C3C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
K 01-162
Cat. No.:
HY-14533
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K 01-162

Cat. No.: HY-14533