2. Neuronal Signaling
  3. Amyloid-β
  4. K 01-162

K 01-162  (Synonyms: K162)

Cat. No.: HY-14533 Purity: ≥98.0%
COA Handling Instructions

K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

K 01-162 Chemical Structure

K 01-162 Chemical Structure

CAS No. : 677746-25-7

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Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

K 01-162 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease[1][2].

In Vitro

K 01-162 (1 μM; 24 h) reduces the level of intracellular AβO[2].
K 01-162 (0.78-50 μM; 5 min) blocks the synaptic binding activity of AβO in mouse hippocampal neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K 01-162 Related Antibodies

Western Blot Analysis[2]

Cell Line: MC65 cell line
Concentration: 1 μM
Incubation Time: 24 hours
Result: Reduced the levels of SDS-stable Aβ trimer and larger aggregates.
In Vivo

K 01-162 (100 μM; intracerebroventricular infusion 0.25 μL/h for 2 weeks) attenuates amyloid load in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5xFAD mice with cerebral Aβ amyloidosis[2]
Dosage: 100 μM
Administration: Intracerebroventricular infusion; 100 μM 0.25 μL/h; for 2 weeks
Result: Caused no apparent toxicity and significantly reduced the amyloid load in hippocampus to 50% of the mock-treated level.
Molecular Weight

288.18

Appearance

Solid

Formula

C15H14BrN
CAS No.
SMILES

BrC1=CC(CC2=C3C=CC(N(C)C)=C2)=C3C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (49.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4701 mL 17.3503 mL 34.7005 mL
5 mM 0.6940 mL 3.4701 mL 6.9401 mL
10 mM 0.3470 mL 1.7350 mL 3.4701 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.43 mg/mL (4.96 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.43 mg/mL (4.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (4.96 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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K 01-162 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

K 01-162677746-25-7K162K 162K-162Amyloid-ββ-amyloid peptideAβAbetaneurotoxicityfibrilADneuronsbrain penetratingintracerebroventricularMC65miceInhibitorinhibitorinhibit

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