1. Neuronal Signaling
  2. Amyloid-β

K 01-162 (Synonyms: K162)

Cat. No.: HY-14533
Handling Instructions

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.

For research use only. We do not sell to patients.
K 01-162 Chemical Structure

K 01-162 Chemical Structure

CAS No. : 677746-25-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $476 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50) Target: Amyloid-β in vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2] in vivo:K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2]

References
Molecular Weight

288.18

Formula

C₁₅H₁₄BrN

CAS No.

677746-25-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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K 01-162
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HY-14533
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