68307-81-3
Chemical Structure
Trioxifene mesylate
Synonym(s): LY133314
- CAS No.: 68307-81-3
- Formula:C31H35NO6S
- Molecular Weight:549.68
IUPAC Name: (2-(4-methoxyphenyl)-3,4-dihydronaphthalen-1-yl)(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)methanone methanesulfonate
InChIKey: RAHJASYQAFJPFD-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=C(OC)C=C2)CCC3=C1C=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4.CS(=O)(O)=O
Biological Activity: Trioxifene mesylate (LY133314) is an orally active and selective estrogen receptor (ER) modulator with human ERα IC50 of 203.49 nM and Ki of 20.84 nM. Trioxifene mesylate binds estradiol receptors, inhibits ERα-mediated gene expression, reduces circulating gonadotrophin levels. Trioxifene mesylate can be used for the research of advanced breast cancer and androgen-independent, metastatic prostatic adenocarcinoma[1][2].
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Trioxifene mesylate | Trioxifene mesylate (LY133314) is an orally active and selective estrogen receptor (ER) modulator with human ERα IC50 of 203.49 nM and Ki of 20.84 nM. Trioxifene mesylate binds estradiol receptors, inhibits ERα-mediated gene expression, reduces circulating gonadotrophin levels. Trioxifene mesylate can be used for the research of advanced breast cancer and androgen-independent, metastatic prostatic adenocarcinoma. | |||||||||||||||||||||
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- [1]. Lee RW, et al. Trioxifene mesylate in the treatment of advanced breast cancer. Cancer. 1986;57(1):40-43. [Content Brief]
- [2]. Neubauer BL, et al. The selective estrogen receptor modulator trioxifene (LY133314) inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model. Cancer Res. 2003;63(18):6056-6062. [Content Brief]
Keywords
