686-07-7
686-07-7
Chemical Structure
S-Methyl-N,N-diethylthiolcarbamate
Synonym(s): DETC-Me; DDTC-Me; Diethyldithiocarbamic acid methyl ester
- CAS No.: 686-07-7
- Formula:C6H13NS2
- Molecular Weight:163.30
IUPAC Name: methyl diethylcarbamodithioate
InChIKey: JYRXPFCUABYLPD-UHFFFAOYSA-N
SMILES: S=C(SC)N(CC)CC
Biological Activity: S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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S-Methyl-N,N-diethylthiolcarbamate | 99.77% | S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation. | ||||||||||||||||||||
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Disulfiram impurity 1-d10 | Disulfiram impurity 1-d10 is the deuterium labeled Disulfiram impurity 1. | |||||||||||||||||||||
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Methyl diethyldithiocarbamate-d3 | 99.95% | Methyl diethyldithiocarbamate-d3 is the deuterium labeled Methyl diethyldithiocarbamate. | ||||||||||||||||||||
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Sulfiram | 96.35% | Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease. | ||||||||||||||||||||
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Ditiocarb | Ditiocarb (Diethyldithiocarbamic acid) is an accelerator of the rate of copper cementation. Ditiocarb (Diethyldithiocarbamic acid) reduces the incidence of HIV infection, and also enhances adjuvant immunoresearch of high risk breast cancer. | |||||||||||||||||||||
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Cyanoethyl dimethyldithiocarbamate | 97.01% | Cyanoethyl dimethyldithiocarbamate, a dithiocarbamate-related substance, is a contact allergen. Cyanoethyl dimethyldithiocarbamate can be found in accelerator-free and conventional nitrile gloves. Cyanoethyl dimethyldithiocarbamate can be used for the research of allergic contact dermatitis. | ||||||||||||||||||||
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Ditiocarb sodium,98% | 99.2% | Ditiocarb sodium,98% (Sodium diethyldithiocarbamate,98%) is an orally active copper reagent. Ditiocarb sodium,98% exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium,98% can be used in the research of tumors, inflammatory, and immune-related diseases. | ||||||||||||||||||||
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N,N-Diethylacetamide | N,N-Diethylacetamide is a polar solvent widely used in film and fiber manufacturing, as well as in laboratories as a carrier for water-insoluble chemicals. N,N-Diethylacetamide exerts potent anti-inflammatory effects by inhibiting the NF-κB pathway, suppressing the expression of NO and iNOS, and downregulating key inflammatory cytokines such as TNF-α and IL-6, without affecting the MAPK pathway. N,N-Diethylacetamide can be used to study inflammatory preterm birth. | |||||||||||||||||||||
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Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% | Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer. | |||||||||||||||||||||
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Silver diethyldithiocarbamate | 98.5% | Silver diethyldithiocarbamate (SDDC) is an organic compound consisting of silver ions complexed with the ligand diethyldithiocarbamate. SDDC is mainly used as a reagent in analytical chemistry to detect the presence of copper, iron and other heavy metals in various materials. It acts as a chelating agent, binding to metal ions and forming stable complexes that can be easily analyzed using techniques such as UV-Vis spectroscopy. | ||||||||||||||||||||
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Diethylglycine | 97.84% | Diethylglycine is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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