70967-97-4
Chemical Structure
Suc-AAPF-pNA
Synonym(s): Suc-Ala-Ala-Pro-Phe-pNA
- CAS No.: 70967-97-4
- Formula:C30H36N6O9
- Molecular Weight:624.64
InChIKey: YHUKYRGKNPQLRF-WJNSRDFLSA-N
SMILES: OC(CCC(N[C@@H](C)C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@H](C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O
Biological Activity: Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the Km of 1.7 mM. Cleavage of Suc-AAPF-pNA releases 4-nitroaniline, which is yellow in colour and can be measured spectrophotometrically. Suc-AAPF-pNA can be used for the measurement of free and membrane-bound cathepsin G in human neutrophils[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Suc-AAPF-pNA | 99.55% | Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the Km of 1.7 mM. Cleavage of Suc-AAPF-pNA releases 4-nitroaniline, which is yellow in colour and can be measured spectrophotometrically. Suc-AAPF-pNA can be used for the measurement of free and membrane-bound cathepsin G in human neutrophils. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Sylvie Attucci, et al. Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates. Biochem J. 2002 Sep 15;366(Pt 3):965-70. [Content Brief]
- [2]. A J Webb, et al. A protease-based biosensor for the detection of schistosome cercariae. Sci Rep. 2016 Apr 19:6:24725. [Content Brief]
- [3]. Jeanette M Mucha, et al. Enhanced immunogenicity of a functional enzyme by T cell epitope modification. BMC Immunol. 2002:3:2. [Content Brief]
Keywords
