71441-09-3
Chemical Structure
Arotinoid
Synonym(s): Ro 13-6298; Arotinoid ethyl ester
- CAS No.: 71441-09-3
- Formula:C26H32O2
- Molecular Weight:376.53
IUPAC Name: ethyl (E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoate
InChIKey: NULUAKSYPPSJCO-FBMGVBCBSA-N
SMILES: CC1(C2=CC(/C(C)=C/C3=CC=C(C(OCC)=O)C=C3)=CC=C2C(C)(C)CC1)C
Biological Activity: Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED50 of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas[1][2].
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Arotinoid | 99.55% | Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED50 of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas. | ||||||||||||||||||||
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Arotinoid (Standard) | Arotinoid (Standard) (Ro 13-6298 (Standard)) is the analytical standard of Arotinoid (HY-106735). This product is intended for research and analytical applications. Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED50 of 0.05 mg/kg. Arotinoid can be used for the research of sKin carcinomas. | |||||||||||||||||||||
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- [1]. Tsambaos D, Orfanos CE. Antipsoriatic activity of a new synthetic retinoid. The arotinoid RO 13-6298. Arch Dermatol. 1983 Sep;119(9):746-51. [Content Brief]
- [2]. Bollag W. Arotinoids. A new class of retinoids with activities in oncology and dermatology. Cancer Chemother Pharmacol. 1981;7(1):27-9. [Content Brief]
Keywords
