71731-58-3
71731-58-3
Chemical Structure
Tiquizium bromide
Synonym(s): HSR-902
- CAS No.: 71731-58-3
- Formula:C19H24BrNS2
- Molecular Weight:410.43
IUPAC Name: (5R,9aR)-3-(di(thiophen-2-yl)methylene)-5-methyldecahydroquinolizin-5-ium bromide
InChIKey: VKBNGRDAHSELMQ-KYSFMIDTSA-M
SMILES: C[N@@+]12C/C(CC[C@@]1([H])CCCC2)=C(C3=CC=CS3)\C4=CC=CS4.[Br-]
Biological Activity: Tiquizium bromide is an orally active, atropine-type, nonselective muscarinic antagonist and novel spasmolytic agent. Tiquizium bromide inhibits the developments of gastric lesions and duodenal lesions. Tiquizium bromide induces the mydoriasis and inhibits the Pilocarpine (HY-B0726A)-induced salivation[1][2].
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Tiquizium bromide | Tiquizium bromide is an orally active, atropine-type, nonselective muscarinic antagonist and novel spasmolytic agent. Tiquizium bromide inhibits the developments of gastric lesions and duodenal lesions. Tiquizium bromide induces the mydoriasis and inhibits the Pilocarpine (HY-B0726A)-induced salivation. | |||||||||||||||||||||
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References
- [1]. Oshita M, et al. Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors. Jpn J Pharmacol. 1987 Jun;44(2):222-4. [Content Brief]
- [2]. Morikawa K, et al. [Evaluation of tiquizium bromide (HSR-902) as an antiulcer agent]. Nihon Yakurigaku Zasshi. 1987 Nov;90(5):273-83. Japanese. [Content Brief]
