7372-30-7
Chemical Structure
Ursolic acid acetate
Synonym(s): Acetylursolic acid; 3-Acetylursolic acid
- CAS No.: 7372-30-7
- Formula:C32H50O4
- Molecular Weight:498.74
IUPAC Name: (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
InChIKey: PHFUCJXOLZAQNH-OTMOLZNZSA-N
SMILES: [H][C@]12C3=CC[C@]4([C@@](CC[C@]5(C(C)([C@H](CC[C@@]54C)OC(C)=O)C)[H])([C@@]3(CC[C@]1(CC[C@H]([C@@H]2C)C)C(O)=O)C)C)[H]
Biological Activity: Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ursolic acid acetate | 98.0% | Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research. | ||||||||||||||||||||
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- [1]. Chiang YM, et al. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry. 2005 Feb;66(4):495-501. [Content Brief]
- [2]. Nndwammbi AAT, et al. Ursolic acid acetate and iso-mukaadial acetate bind to Plasmodium falciparum Hsp90, abrogating its chaperone function in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul;397(7):5179-5192. [Content Brief]
- [3]. Gnoatto S C B, et al. Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl) piperazinyl] propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Bioorganic & medicinal chemistry, 2008, 16(2): 771-782.
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