74209-34-0
74209-34-0
Chemical Structure
3-Bromo-7-nitroindazole
- No. CAS: 74209-34-0
- Formula:C7H4BrN3O2
- Molecular Weight:242.03
IUPAC Name: 3-bromo-7-nitro-1H-indazole
InChIKey: NFSTZPMYAZRZPC-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=CC2=C1NN=C2Br)[O-]
Biological Activity: 3-Bromo-7-nitroindazole is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain. 3-Bromo-7-nitroindazole can be used for the researches of metabolic and neurological disease, such as diabetes, stroke and depression[1][2][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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3-Bromo-7-nitroindazole | 99.78% | 3-Bromo-7-nitroindazole is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain. 3-Bromo-7-nitroindazole can be used for the researches of metabolic and neurological disease, such as diabetes, stroke and depression. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-690197-Nitroindazole -
Similarity Score 0.81
HY-797153-Methyl-6-nitro-1H-indazole -
Similarity Score 0.79
HY-W0474325-Nitro-1H-indazole-3-carbonitrile -
Similarity Score 0.78
HY-W0019747-Nitroindole -
Similarity Score 0.77
HY-69019A7-Nitroindazole sodium -
Similarity Score 0.77
HY-401584-Nitroindole -
Similarity Score 0.77
HY-W022047nNOS-IN-1 -
Similarity Score 0.75
HY-W0408862-Bromo-6-nitrophenol -
Similarity Score 0.74
HY-W0141591-Bromo-2-methyl-3-nitrobenzene -
Explore the MedChemAI to find more analogs
References
- [1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25. [Content Brief]
- [2]. Srinivasan K, et al. 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP. Life Sci. 2012 Jan 16;90(3-4):154-60. [Content Brief]
- [3]. Yazir Y, et al. Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress. Basic Clin Pharmacol Toxicol. 2012 Sep;111(3):154-60. [Content Brief]
