74720-33-5
74720-33-5
Chemical Structure
Piperafizine B
- CAS No.: 74720-33-5
- Formula:C18H14N2O2
- Molecular Weight:290.32
IUPAC Name: 3,6-di((Z)-benzylidene)piperazine-2,5-dione
InChIKey: RFSUEJIDSYCCLL-NFLUSIDLSA-N
SMILES: O=C(/C(NC/1=O)=C/C2=CC=CC=C2)NC1=C/C3=CC=CC=C3
Biological Activity: Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC50s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model[1].
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Piperafizine B | Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC50s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model. | |||||||||||||||||||||
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