75629-57-1
Chemical Structure
Oncrasin-1
- CAS No.: 75629-57-1
- Formula:C16H12ClNO
- Molecular Weight:269.73
IUPAC Name: 1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde
InChIKey: ZDRQMXCSSAPUMM-UHFFFAOYSA-N
SMILES: O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
Biological Activity: Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer[1][2].
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Oncrasin-1 | 98.16% | Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer. | ||||||||||||||||||||
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Similarity Score 0.83
HY-122315Oncrasin-60 -
Similarity Score 0.75
HY-116074FUB-PB-22 3-carboxyindole metabolite -
Similarity Score 0.74
HY-130207Oncrasin-72 -
Similarity Score 0.71
HY-W0301202-(1-(4-Fluorobenzyl)-1H-indol-3-yl)acetic acid -
Similarity Score 0.71
HY-N101591-Benzyl-I3C -
Similarity Score 0.69
HY-B1144AChlormidazole hydrochloride -
Similarity Score 0.66
HY-101858RBQCA (Standard) -
Similarity Score 0.63
![2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole Chemical Structure](//file.medchemexpress.com/product_pic/hy-w011786.gif)
HY-W0117862-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole -
Similarity Score 0.62
HY-108637APhiKan 083 hydrochloride -
Explore the MedChemAI to find more analogs
![2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w011786.gif)
References
- [1]. Guo W, et al. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. Cancer Res. 2008 Sep 15;68(18):7403-8. [Content Brief]
- [2]. Guo W, et al. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther. 2009 Feb;8(2):441-8. [Content Brief]
