76420-72-9
76420-72-9
Chemical Structure
Enalaprilat
Synonym(s): MK-422 anhydrous
- CAS No.: 76420-72-9
- Formula:C18H24N2O5
- Molecular Weight:348.39
IUPAC Name: ((S)-1-carboxy-3-phenylpropyl)-L-alanyl-L-proline
InChIKey: LZFZMUMEGBBDTC-QEJZJMRPSA-N
SMILES: O=C(O)[C@H]1N(C([C@H](C)N[C@H](C(O)=O)CCC2=CC=CC=C2)=O)CCC1
Biological Activity: Enalaprilat (MK-422 anhydrous), the active metabolite of the oral proagent Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Enalaprilat | 99.52% | Enalaprilat (MK-422 anhydrous), the active metabolite of the oral proagent Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension. | ||||||||||||||||||||
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Enalaprilat-d5 maleate | Enalaprilat-d5 (maleate) is the deuterium labeled Enalaprilat maleate. | |||||||||||||||||||||
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Enalaprilat-d5 | 99.47% | Enalaprilat-d5 is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor. | ||||||||||||||||||||
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References
- [1]. Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [Content Brief]
- [2]. Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6. [Content Brief]
- [3]. Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41. [Content Brief]
