76958-97-9
76958-97-9
Chemical Structure
Acipimox sodium
Synonym(s): K-9321 sodium
- CAS No.: 76958-97-9
- Formula:C6H5N2NaO3
- Molecular Weight:176.11
IUPAC Name: sodium 6-methyl-1-oxidopyrazine-3-carboxylate
InChIKey: APTVATQAOBWAAS-UHFFFAOYSA-M
SMILES: O=C(C1=C[N+]([O-])=C(C)C=N1)O[Na]
Biological Activity: Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity[1][2][3].
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Acipimox sodium | Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity. | |||||||||||||||||||||
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References
- [1]. Vestergaard ET, et, al. Short-term acipimox treatment is associated with decreased cardiac parasympathetic modulation. Br J Clin Pharmacol. 2017 Dec;83(12):2671-2677. [Content Brief]
- [2]. Wang-Fisher YL, et, al. Acipimox stimulates leptin production from isolated rat adipocytes. J Endocrinol. 2002 Aug;174(2):267-72. [Content Brief]
- [3]. Ahrén B. Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice. Acta Physiol Scand. 2001 Feb;171(2):161-7. [Content Brief]
Keywords
