78466-98-5
Chemical Structure
Razobazam
Synonym(s): Hoe 175
- CAS No.: 78466-98-5
- Formula:C14H14N4O2
- Molecular Weight:270.29
IUPAC Name: 3,8-dimethyl-4-phenyl-4,8-dihydropyrazolo[3,4-b][1,4]diazepine-5,7(1H,6H)-dione
InChIKey: RHZDHINXKVZTEF-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(N(C)C(C1)=O)NN=C2C)C3=CC=CC=C3
Biological Activity: Razobazam (Hoe 175) is a benzodiazepine derivative with cognitive activity. Razobazam has been shown to improve learning performance in socially deprived rats. Razobazam increased avoidance scores by 18% after training. Razobazam caused significant changes in the optical density of certain areas of the rat brain, including a 22% decrease in the lateral habenula and a 25% increase in the ventral tegmental area. Razobazam also caused a 13% increase in optical density in the prefrontal cortex of rats[1].
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Razobazam | Razobazam (Hoe 175) is a benzodiazepine derivative with cognitive activity. Razobazam has been shown to improve learning performance in socially deprived rats. Razobazam increased avoidance scores by 18% after training. Razobazam caused significant changes in the optical density of certain areas of the rat brain, including a 22% decrease in the lateral habenula and a 25% increase in the ventral tegmental area. Razobazam also caused a 13% increase in optical density in the prefrontal cortex of rats. | |||||||||||||||||||||
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