79467-24-6
79467-24-6
Chemical Structure
Mioflazine (di(hydrochloride) hydrate)
- CAS No.: 79467-24-6
- Formula:C29H34Cl4F2N4O3
- Molecular Weight:666.41
InChIKey: CAEGSEJNBXUDOD-UHFFFAOYSA-N
SMILES: O=C(C1N(CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CCN(C1)CC(NC4=C(Cl)C=CC=C4Cl)=O)N.Cl.Cl.O
Biological Activity: Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig[1][2][3][4].
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Mioflazine (di(hydrochloride) hydrate) | Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig. | |||||||||||||||||||||
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References
- [1]. Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl). 1987;91(4):434-9. [Content Brief]
- [2]. Mioflazine, a potentially protective drug against ischaemic damage: a study in dogs [Content Brief]
- [3]. Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189(6):419-22. [Content Brief]
- [4]. J G Hugtenburg, et al. The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts. Eur J Pharmacol. 1990 Mar 13;178(1):71-8. [Content Brief]
