80152-07-4
80152-07-4
Chemical Structure
Streptazolin
- CAS No.: 80152-07-4
- Formula:C11H13NO3
- Molecular Weight:207.23
IUPAC Name: (2S,2aS,2a1S,Z)-1-ethylidene-2-hydroxy-1,2,2a,2a1,5,6-hexahydro-4H-3-oxa-4a-azacyclopenta[cd]inden-4-one
InChIKey: OJIUACOQFBQCDF-IKXJTIOISA-N
SMILES: C/C=C1C([C@@]2([H])[C@@](O3)([H])[C@H]/1O)=CCCN2C3=O
Biological Activity: Streptazolin is an antibiotic. Streptazolin increases bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Streptazolin stimulates the macrophage NF-κB pathway via PI3K signaling[1][2].
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Streptazolin | Streptazolin is an antibiotic. Streptazolin increases bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Streptazolin stimulates the macrophage NF-κB pathway via PI3K signaling. | |||||||||||||||||||||
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References
- [1]. Groenhagen U, et al. Streptopyridines, volatile pyridine alkaloids produced by Streptomyces sp. FORM5. Beilstein J Org Chem. 2014;10:1421-1432. Published 2014 Jun 24. [Content Brief]
- [2]. Perry JA, et al. A macrophage-stimulating compound from a screen of microbial natural products. J Antibiot (Tokyo). 2015;68(1):40-46. [Content Brief]
Keywords
