80828-34-8
80828-34-8
Chemical Structure
Indolaprilat
- CAS No.: 80828-34-8
- Formula:C22H30N2O5
- Molecular Weight:402.48
InChIKey: AHYHTSYNOHNUSH-GBBGEASQSA-N
SMILES: OC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@]3([H])[C@](CCCC3)([H])C[C@H]2C(O)=O)=O)=O
Biological Activity: Indolaprilat is an ACE inhibitor with an IC50 value of 3.0 nM. Indolaprilat also inhibits aminopeptidase P, with an IC50 of 485 μM for aminopeptidase P. Indolaprilat inhibits the zinc metallopeptidase-mediated cleavage of angiotensin I, Bradykinin (HY-P0206), and proline-containing oligopeptides. Indolaprilat can be used in related research on hypertension and congestive heart failure[1][2].
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Indolaprilat | Indolaprilat is an ACE inhibitor with an IC50 value of 3.0 nM. Indolaprilat also inhibits aminopeptidase P, with an IC50 of 485 μM for aminopeptidase P. Indolaprilat inhibits the zinc metallopeptidase-mediated cleavage of angiotensin I, Bradykinin (HY-P0206), and proline-containing oligopeptides. Indolaprilat can be used in related research on hypertension and congestive heart failure. | |||||||||||||||||||||
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References
- [1]. Hooper NM, et al. Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P. Hypertension (Dallas, Tex. : 1979). 1992 Mar;19(3):281-5.
- [2]. Blankley CJ, et al. Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids. J Med Chem. 1987 Jun;30(6):992-8.
