Indolaprilat
Indolaprilat is an ACE inhibitor with an IC50 value of 3.0 nM. Indolaprilat also inhibits aminopeptidase P, with an IC50 of 485 μM for aminopeptidase P. Indolaprilat inhibits the zinc metallopeptidase-mediated cleavage of angiotensin I, Bradykinin (HY-P0206), and proline-containing oligopeptides. Indolaprilat can be used in related research on hypertension and congestive heart failure.
For research use only. We do not sell to patients.
- CAS No.: 80828-34-8
- Formula: C22H30N2O5
- Molecular Weight:402.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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ACE 3 nM (IC50) |
aminopeptidase P 485 μM (IC50) |
In Vitro
Indolaprilat (1 mM; 5 min) inhibits purified porcine renal cortical aminopeptidase P with an IC50 of 485 μM, and also inhibits purified porcine renal angiotensin-converting enzyme with an IC50 of 3.0 nM[1].
Indolaprilat exhibits potent angiotensin-converting enzyme (ACE) inhibitory activity in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 80828-34-8
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Molecular Weight 402.48
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Formula C22H30N2O5
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SMILES
OC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@]3([H])[C@](CCCC3)([H])C[C@H]2C(O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indolaprilat Related Classifications
HY-187709 Related Classifications
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