81012-87-5
Chemical Structure
Cytidine-5'-triphosphate disodium dihydrate
Synonym(s): Cytidine triphosphate disodium dihydrate; 5'-CTP disodium dihydrate
- CAS No.: 81012-87-5
- Formula:C9H18N3Na2O16P3
- Molecular Weight:563.15
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen triphosphate dihydrate
InChIKey: KNSYTSUGTLJHPS-ODQFIEKDSA-L
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O)=O.O.O
Biological Activity: Cytidine-5'-triphosphate disodium dihydrate (Cytidine triphosphate disodium dihydrate) is a nucleoside triphosphate and a substrate of CMP-KDO synthase, forming CMP-KDO. Cytidine-5'-triphosphate disodium dihydrate is a precursor of RNA/DNA, phospholipids, and sialoglycoproteins, is reduced to dCTP by deoxycytidylate-generating reductase, and can be used for the biosynthesis of phosphatidic acid to CDP-DG/cardiolipin[1][2][3][4][5][6][7][8].
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Cytidine-5'-triphosphate disodium dihydrate | Cytidine-5'-triphosphate disodium dihydrate (Cytidine triphosphate disodium dihydrate) is a nucleoside triphosphate and a substrate of CMP-KDO synthase, forming CMP-KDO. Cytidine-5'-triphosphate disodium dihydrate is a precursor of RNA/DNA, phospholipids, and sialoglycoproteins, is reduced to dCTP by deoxycytidylate-generating reductase, and can be used for the biosynthesis of phosphatidic acid to CDP-DG/cardiolipin. | |||||||||||||||||||||
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Similarity Score 0.92
HY-125818ICTP disodium salt, 100 mM Solution, PCR Grade -
Similarity Score 0.88
HY-115740ACytarabine triphosphate trisodium -
Similarity Score 0.88
HY-125818DCytidine-5'-triphosphate trisodium -
Similarity Score 0.85
HY-W008940Cytidine 5'-diphosphate disodium salt -
Similarity Score 0.83
HY-115740Cytarabine triphosphate -
Similarity Score 0.83
HY-125818Cytidine-5'-triphosphate -
Similarity Score 0.83
HY-W754064Cytidine-5'-triphosphate-13C5 -
Similarity Score 0.79
HY-W008915Cytidine 5'-diphosphate trisodium salt -
Similarity Score 0.78
HY-113400Cytidine 5'-diphosphate -
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References
- [1]. Boghaei DM, et al. Spectrophotometric studies of molecular complex formation between water-soluble cobalt(II) Schiff base complex and nucleotides in mixed solvent systems. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2005 Oct;61(13-14):3061-5. [Content Brief]
- [2]. Simon ES, et al. Convenient Syntheses of Cytidine 5'-Triphosphate, Guanosine 5'-Triphosphate, and Uridine 5'-Triphosphate and Their Use in the Preparation of UDP-glucose, UDP-glucuronic Acid, and GDP-mannose. J Org Chem. 1990;55(6):1834-1841.
- [3]. Kizaki H, et al. Increased cytidine 5'-triphosphate synthetase activity in rat and human tumors. Cancer Res. 1980 Nov;40(11):3921-7.
- [4]. Ray PH, et al. Purification and characterization of cytidine 5'-triphosphate:cytidine 5'-monophosphate-3-deoxy-D-manno-octulosonate cytidylyltransferase. Journal of bacteriology. 1981 Mar;145(3):1273-80.
- [5]. Abrams R. Cytidine 5'-Triphosphate as the Precursor of Deoxycytidylate in Lactobacillus leichmannii. J Biol Chem. 1965;240(9):PC3697.
- [6]. Von der Saal W, et al. Cytidine-5'-triphosphate synthetase catalyzes the phosphorylation of uridine 5'-triphosphate by adenosine 5'-triphosphate. J Am Chem Soc. 1985;107(3):703-704.
- [7]. van Haperen VW, Vet al. Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine. Biochem Pharmacol. 1996 Apr 12;51(7):911-8.
- [8]. Hatch GM, et al. Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. J Biol Chem. 1996 Oct 18;271(42):25810-6. [Content Brief]
