81047-99-6
Chemical Structure
CGP 12177
Synonym(s): (±)-CGP 12177
- CAS No.: 81047-99-6
- Formula:C14H21N3O3
- Molecular Weight:279.33
IUPAC Name: 4-(3-(tert-butylamino)-2-hydroxypropoxy)-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChIKey: UMQUQWCJKFOUGV-UHFFFAOYSA-N
SMILES: O=C1NC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1
Biological Activity: CGP 12177 ((±)-CGP 12177) is a β-Adrenergic receptor (β-AR) ligand. CGP 12177 is a β3-AR (Ki = 88 nM) agonist with β1/β2-AR (Ki = 0.9 nM for β1; Ki = 4 nM for β2) antagonist action. CGP 12177 exhibits partial agonist properties for α1-AR in rat pulmonary artery. CGP 12177 regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 can be used for cardiovascular and metabolic disease research[1][2][3][4].
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CGP 12177 | CGP 12177 ((±)-CGP 12177) is a β-Adrenergic receptor (β-AR) ligand. CGP 12177 is a β3-AR (Ki = 88 nM) agonist with β1/β2-AR (Ki = 0.9 nM for β1; Ki = 4 nM for β2) antagonist action. CGP 12177 exhibits partial agonist properties for α1-AR in rat pulmonary artery. CGP 12177 regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 can be used for cardiovascular and metabolic disease research. | |||||||||||||||||||||
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- [1]. Leblais V, et al. Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. J Pharmacol Exp Ther. 2004 Apr;309(1):137-45. [Content Brief]
- [2]. Baker JG, et al. Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor. Br J Pharmacol. 2002 Oct;137(3):400-8. [Content Brief]
- [3]. Oliver P, et al. In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues. Int J Obes Relat Metab Disord. 2000 Apr;24(4):423-8. [Content Brief]
- [4]. Strosberg AD, et al. Function and regulation of the beta 3-adrenoceptor. Trends Pharmacol Sci. 1996 Oct;17(10):373-81. [Content Brief]
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