81996-46-5
Chemical Structure
KMUP-1
- CAS No.: 81996-46-5
- Formula:C19H23ClN6O2
- Molecular Weight:402.88
IUPAC Name: 7-(2-(4-(2-chlorophenyl)piperazin-1-yl)ethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: NIDVDYQCGWISJZ-UHFFFAOYSA-N
SMILES: O=C(N1C)N(C)C2=C(N(CCN3CCN(C4=CC=CC=C4Cl)CC3)C=N2)C1=O
Biological Activity: KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC). KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K+ channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study[1][2].
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KMUP-1 | KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC). KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K+ channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study. | |||||||||||||||||||||
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- [1]. Wu BN, et al. A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle. Br J Pharmacol. 2001 Sep;134(2):265-74. [Content Brief]
- [2]. Lee ML, et al. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways. Molecules. 2019 Apr 8;24(7):1376. [Content Brief]
Keywords
