82473-24-3
Chemical Structure
CHAPSO
Synonym(s): 3-[3-(Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate
- CAS No.: 82473-24-3
- Formula:C32H58N2O8S
- Molecular Weight:630.88
IUPAC Name: 3-(dimethyl(3-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propyl)ammonio)-2-hydroxypropane-1-sulfonate
InChIKey: GUQQBLRVXOUDTN-XOHPMCGNSA-N
SMILES: O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(NCCC[N+](C)(C)CC(O)CS(=O)([O-])=O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C
Biological Activity: CHAPSO is a bile derivative. CHAPSO reduces protein adsorption, improves the cryo-EM imaging quality. CHAPSO can be used as a detergent, or as the membrane protein solubilization and reconstruction reagent in membrane protein structural studies[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CHAPSO | 99.82% | CHAPSO is a bile derivative. CHAPSO reduces protein adsorption, improves the cryo-EM imaging quality. CHAPSO can be used as a detergent, or as the membrane protein solubilization and reconstruction reagent in membrane protein structural studies. | ||||||||||||||||||||
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References
- [1]. Li M, et al. Morphological characterization of DMPC/CHAPSO bicellar mixtures: a combined SANS and NMR study. Langmuir. 2013 Dec 23;29(51):15943-57. [Content Brief]
- [2]. Chen J, et al. Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO. J Struct Biol X. 2019 Jan-Mar;1:100005. [Content Brief]
- [3]. Cladera J, et al., Liposome solubilization and membrane protein reconstitution using Chaps and Chapso. Eur J Biochem. 1997 Feb 1;243(3):798-804. [Content Brief]
