83519-04-4
83519-04-4
Chemical Structure
Ilmofosine
Synonym(s): BM41440
- CAS No.: 83519-04-4
- Formula:C26H56NO5PS
- Molecular Weight:525.77
IUPAC Name: 3-(hexadecylthio)-2-(methoxymethyl)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: ODEDPKNSRBCSDO-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCCCCCSCC(COC)COP(OCC[N+](C)(C)C)([O-])=O
Biological Activity: Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent[1][2].
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Ilmofosine | Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent. | |||||||||||||||||||||
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References
- [1]. Croft SL, et al. Antileishmanial activity of the ether phospholipid ilmofosine. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):217-9. [Content Brief]
- [2]. Hofmann J, et al. The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. Biochem Biophys Res Commun. 1994 Mar 15;199(2):937-43. [Content Brief]
Keywords
