Antileishmanial activity of the ether phospholipid ilmofosine

  • Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):217-9. doi: 10.1016/0035-9203(93)90499-g.
S L Croft  1 ,  R A Neal ,  E A Thornton ,  D B Herrmann
Affiliations
  • 1. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
PMID: 8337733 DOI: 10.1016/0035-9203(93)90499-g
Abstract

The ether phospholipid ilmofosine (BM 41.440) was active in vitro against amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum in mouse peritoneal macrophages with ED50 values of 3.7 microM and 3.5 microM respectively. Ilmofosine was also active against L. donovani in BALB/c mice following oral and subcutaneous dosing, with an ED50 value of 10.5 mg/kg x 5 by the oral route.

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