84-96-8
84-96-8
Chemical Structure
Alimemazine
Synonym(s): Trimeprazine
- CAS No.: 84-96-8
- Formula:C18H22N2S
- Molecular Weight:298.45
IUPAC Name: N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
InChIKey: ZZHLYYDVIOPZBE-UHFFFAOYSA-N
SMILES: CC(CN(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C31
Biological Activity: Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties[1][2].
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Alimemazine | Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties. | |||||||||||||||||||||
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References
- [1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64. [Content Brief]
- [2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3). [Content Brief]
