849662-80-2
Chemical Structure
Y134
- CAS No.: 849662-80-2
- Formula:C28H28N2O3S
- Molecular Weight:472.60
IUPAC Name: (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(4-isopropylpiperazin-1-yl)phenyl)methanone
InChIKey: LQEOPHGPHCWOAC-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(N5CCN(C(C)C)CC5)C=C4
Biological Activity: Y134 is a selective and orally active oestrogen receptor (ER) modulator (SERM), exhibits potent antagonist activity at ERα and ERβ. Y134 shows 121.1-fold selectivity for ERα (Ki=0.09 nM) over ERβ (Ki=11.31 nM). Y134 inhibits oestrogen-stimulated proliferation of ER-positive human breast cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Y134 | 99.67% | Y134 is a selective and orally active oestrogen receptor (ER) modulator (SERM), exhibits potent antagonist activity at ERα and ERβ. Y134 shows 121.1-fold selectivity for ERα (Ki=0.09 nM) over ERβ (Ki=11.31 nM). Y134 inhibits oestrogen-stimulated proliferation of ER-positive human breast cancer cells. | ||||||||||||||||||||
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Similarity Score 0.74
HY-135585LY88074 -
Similarity Score 0.74
HY-135592LY88074 Methyl ether -
Similarity Score 0.74
HY-116896LY117018 -
Similarity Score 0.73
HY-13738RRaloxifene (Standard) -
Similarity Score 0.72
HY-13738ARaloxifene hydrochloride -
Similarity Score 0.71
HY-176560Raloxifene alkene -
Similarity Score 0.71
HY-48027ERα ligand 5 -
Similarity Score 0.70
HY-135593LY88074 analog 1 -
Similarity Score 0.70
HY-179045ERα degrader 14 -
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