851518-71-3
851518-71-3
Chemical Structure
Hydronidone
- CAS No.: 851518-71-3
- Formula:C12H11NO2
- Molecular Weight:201.22
IUPAC Name: 1-(4-hydroxyphenyl)-5-methylpyridin-2(1H)-one
InChIKey: NETTXQJYJRFTFS-UHFFFAOYSA-N
SMILES: O=C1C=CC(C)=CN1C2=CC=C(O)C=C2
Biological Activity: Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hydronidone | 99.71% | Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study. | ||||||||||||||||||||
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Hydronidone (Standard) | ≥98% | Hydronidone (Standard) is the analytical standard of Hydronidone (HY-100438). This product is intended for research and analytical applications. Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study. | ||||||||||||||||||||
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References
- [1]. Xu X, et al. Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI. Liver Int. 2023 Nov;43(11):2523-2537. [Content Brief]
- [2]. Sun Z, et al. Hydronidone induces apoptosis in activated hepatic stellate cells through endoplasmic reticulum stress-associated mitochondrial apoptotic pathway. J Gastroenterol Hepatol. 2024 Aug;39(8):1695-1703. [Content Brief]
- [3]. Juillerat-Jeanneret L, et al. Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem. 2018 Nov 21;61(22):9811-9840. [Content Brief]
Keywords
