862281-92-3
862281-92-3
Chemical Structure
PF-00446687 free base
- CAS No.: 862281-92-3
- Formula:C28H36F2N2O2
- Molecular Weight:470.59
IUPAC Name: ((3S,4R)-1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3R,4S,5S)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
InChIKey: WHPJOAUPIZDJNX-AARYPEPZSA-N
SMILES: O=C(N(C[C@@H]1C)C[C@H]([C@@]1(O)C2=CC=CC=C2)C)[C@H](C3)[C@H](C(C=CC(F)=C4)=C4F)CN3C(C)(C)C
Biological Activity: PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM[1]. Pf-446687 is brain penetrant[2].
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PF-00446687 free base | 98.02% | PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM. Pf-446687 is brain penetrant. | ||||||||||||||||||||
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PF-00446687 free base (Standard) | ≥98% | PF-00446687 free base (Standard) is the analytical standard of PF-00446687 free base (HY-10622). This product is intended for research and analytical applications. PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM. Pf-446687 is brain penetrant. | ||||||||||||||||||||
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References
- [1]. Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53(8):3183-97. [Content Brief]
- [2]. Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65. [Content Brief]
