869853-70-3
869853-70-3
Chemical Structure
VAS 3947
- CAS No.: 869853-70-3
- Formula:C14H10N6OS
- Molecular Weight:310.33
IUPAC Name: 2-((3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole
InChIKey: JVZDLDFNSCFLPM-UHFFFAOYSA-N
SMILES: C12=NC=NC(SC3=NC=CO3)=C1N=NN2CC4=CC=CC=C4
Biological Activity: VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[1][2].
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VAS 3947 | 99.59% | VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins. | ||||||||||||||||||||
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References
- [1]. Wind S, et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol. 2010;161(4):885-898. [Content Brief]
- [2]. El Dor M, et al. VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines. Int J Mol Sci. 2020;21(15):5470. Published 2020 Jul 31. [Content Brief]
Keywords
