872363-17-2
Chemical Structure
Dipraglurant
Synonym(s): ADX48621
- CAS. Nr.: 872363-17-2
- Formula:C16H12FN3
- Molecular Weight:265.29
IUPAC Name: 6-fluoro-2-(4-(pyridin-2-yl)but-3-yn-1-yl)imidazo[1,2-a]pyridine
InChIKey: LZXMUJCJAWVHPZ-UHFFFAOYSA-N
SMILES: FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2
Biological Activity: Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo[1][2]. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Dipraglurant | 99.97% | Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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