89943-82-8
89943-82-8
Chemical Structure
Cicletanine
- CAS. Nr.: 89943-82-8
- Formula:C14H12ClNO2
- Molecular Weight:261.70
InChIKey: CVKNDPRBJVBDSS-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2OCC3=C(C(C)=NC=C32)O)C=C1
Biological Activity: Cicletanine is a voltage-dependent Ca2+ channel inhibitor. Cicletanine inhibits α-adrenoceptor-mediated Ca2+ release pathway, and shows vasodilatory effects on isolated vascular smooth muscle. Cicletanine directly stimulates lysosomal and cytoplasmic cholesteryl ester hydrolase activity. Cicletanine can be used for the research of hypertension[1][2].
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Cicletanine | Cicletanine is a voltage-dependent Ca2+ channel inhibitor. Cicletanine inhibits α-adrenoceptor-mediated Ca2+ release pathway, and shows vasodilatory effects on isolated vascular smooth muscle. Cicletanine directly stimulates lysosomal and cytoplasmic cholesteryl ester hydrolase activity. Cicletanine can be used for the research of hypertension. | |||||||||||||||||||||
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References
- [1]. Izumi M, et al. Cicletanine-induced decreases in cytosolic Ca2+ level and contraction in vascular smooth muscle. Jpn J Pharmacol. 1998;76(1):57-63. [Content Brief]
- [2]. Hajjar DP, et al. Cicletanine stimulates cholesteryl ester hydrolase activities and prostacyclin production in arterial smooth muscle cells. Arch Mal Coeur Vaiss. 1989;82 Spec No 4:79-84. [Content Brief]
Keywords
