90139-06-3
Chemical Structure
Cilazaprilat
Synonym(s): Ro 31-3113
- CAS No.: 90139-06-3
- Formula:C20H27N3O5
- Molecular Weight:389.45
IUPAC Name: (1S,9S)-9-(((S)-1-carboxy-3-phenylpropyl)amino)-10-oxooctahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
InChIKey: UVAUYSRYXACKSC-ULQDDVLXSA-N
SMILES: O=C([C@@H]1CCCN2N1C([C@@H](N[C@H](C(O)=O)CCC3=CC=CC=C3)CCC2)=O)O
Biological Activity: Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.
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Cilazaprilat | Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia. | |||||||||||||||||||||
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Cilazaprilat-d5 | Cilazaprilat-d5 is the deuterium labeled Cilazaprilat. | |||||||||||||||||||||
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Keywords
