907166-59-0
907166-59-0
Chemical Structure
MI-223
- CAS No.: 907166-59-0
- Formula:C23H18ClN3O3
- Molecular Weight:419.86
IUPAC Name: (E)-2-(2-chlorophenyl)-3-((3-ethoxy-2-hydroxybenzylidene)amino)quinazolin-4(3H)-one
InChIKey: DMEZDUZTJMMDKT-AFUMVMLFSA-N
SMILES: O=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
Biological Activity: MI-223 is a Mcl-1 regulator (Kd = 160 nM). MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer[1].
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MI-223 | MI-223 is a Mcl-1 regulator (Kd = 160 nM). MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer. | |||||||||||||||||||||
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References
Keywords
