907206-98-8
Chemical Structure
SCH-900875
- CAS No.: 907206-98-8
- Formula:C28H37ClN8O2
- Molecular Weight:553.10
InChIKey: MDHIGNOFHUSPMA-GCJKJVERSA-N
SMILES: O=C(C1=CC=C(Cl)C=C1)N2CCC(N3[C@@H](CC)CN(C4=NC=C(C5=NN=C(NCC)O5)N=C4C)[C@H](C)C3)CC2
Biological Activity: SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SCH-900875 | 98.16% | SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
