9076-44-2
9076-44-2
Chemical Structure
Chymostatin
- CAS. Nr.: 9076-44-2
- Formula:N/A
- Molecular Weight:607.70
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
Biological Activity: Chymostatin is a SARS-CoV-2 Mpro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer[1][2][3][4][5][6][7].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Chymostatin | 99.9% | Chymostatin is a SARS-CoV-2 Mpro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer. | ||||||||||||||||||||
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References
- [1]. Chen Yang, et al. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation [Content Brief]
- [2]. Lane JT, et al. Chymostatin inhibits cellular aggregation of activated human peripheral blood lymphocytes. Life Sci. 1980 Aug 11;27(6):451-6. [Content Brief]
- [3]. Qiu M, et al. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells. Lipids Health Dis. 2018 Jul 31;17(1):183. [Content Brief]
- [4]. Abstract LB074: Chymostatin, a cathepsin L inhibitor, inhibits lung cancer cell proliferation and COVID-19 Mpro in vitro.
- [5]. Libby P, et al. Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J. 1980 Apr 15;188(1):213-20. [Content Brief]
- [6]. Roszkowska-Chojecka MM, et al. Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat. Exp Physiol. 2015 Sep;100(9):1093-105. [Content Brief]
- [7]. Komatsu K, et al. Beneficial effect of chymostatin on dystrophic mice. Exp Neurol. 1986 Jul;93(1):110-6. [Content Brief]
Keywords
