917562-33-5
917562-33-5
Chemical Structure
JT010
- CAS No.: 917562-33-5
- Formula:C16H19ClN2O3S
- Molecular Weight:354.85
IUPAC Name: 2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide
InChIKey: KZMAWJRXKGLWGS-UHFFFAOYSA-N
SMILES: O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
Biological Activity: JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JT010 | 99.48% | JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64. [Content Brief]
- [2]. Szabó K, et al. TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation. Biomolecules. 2024 May 28;14(6):632. [Content Brief]
- [3]. Matsubara M, et al. Potent Activation of Human but Not Mouse TRPA1 by JT010. Int J Mol Sci. 2022 Nov 18;23(22):14297. [Content Brief]
- [4]. Virk HS, et al. TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels. Br J Pharmacol. 2021 Aug;178(15):2948-2962. [Content Brief]
- [5]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach. Clin Exp Allergy. 2025 Jan 21. [Content Brief]
- [6]. Hoebart C, Kiss A, Pilz PM, Szabo PL, Podesser BK, Fischer MJM, Heber S. TRPA1 as Target in Myocardial Infarction. Int J Mol Sci. 2023 Jan 28;24(3):2516. [Content Brief]
Keywords
