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Cat. No.: HY-111132R

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JT010 (Standard)

JT010 (Standard) is the analytical standard of JT010 (HY-111132). This product is intended for research and analytical applications. JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research.

For research use only. We do not sell to patients.

CAS No.: 917562-33-5
Formula: C₁₆H₁₉ClN₂O₃S
Molecular Weight:354.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JT010 (Standard) Chemical Structure

CAS No.: 917562-33-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 917562-33-5
Molecular Weight 354.85
Formula C₁₆H₁₉ClN₂O₃S
SMILES

O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64. [Content Brief]

[2]. Szabó K, et al. TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation. Biomolecules. 2024 May 28;14(6):632. [Content Brief]

[3]. Matsubara M, et al. Potent Activation of Human but Not Mouse TRPA1 by JT010. Int J Mol Sci. 2022 Nov 18;23(22):14297. [Content Brief]

[4]. Virk HS, et al. TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels. Br J Pharmacol. 2021 Aug;178(15):2948-2962. [Content Brief]

[5]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach. Clin Exp Allergy. 2025 Jan 21. [Content Brief]

[6]. Hoebart C, Kiss A, Pilz PM, Szabo PL, Podesser BK, Fischer MJM, Heber S. TRPA1 as Target in Myocardial Infarction. Int J Mol Sci. 2023 Jan 28;24(3):2516. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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