926023-82-7
926023-82-7
Chemical Structure
AMTB hydrochloride
- CAS. Nr.: 926023-82-7
- Formula:C23H27ClN2O2S
- Molecular Weight:430.99
IUPAC Name: N-(3-aminopropyl)-2-((3-methylbenzyl)oxy)-N-(thiophen-2-ylmethyl)benzamide hydrochloride
InChIKey: UDXGBANGPYONOK-UHFFFAOYSA-N
SMILES: O=C(N(CCCN)CC1=CC=CS1)C2=CC=CC=C2OCC3=CC=CC(C)=C3.[H]Cl
Biological Activity: AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV)[1][2].
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AMTB hydrochloride | 99.08% | AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV). | ||||||||||||||||||||
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References
- [1]. Lashinger ES, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008;295(3):F803-F810. [Content Brief]
- [2]. Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135. [Content Brief]
