928821-41-4
Chemical Structure
Seladelpar (lysine)
Synonym(s): MBX-8025 (lysine); RWJ-800025 (lysine)
- CAS No.: 928821-41-4
- Formula:C27H37F3N2O7S
- Molecular Weight:590.65
IUPAC Name: L-lysine compound with (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid (1:1)
InChIKey: IOIAOZMQFNHRKR-FFHLUDTASA-N
SMILES: N[C@@H](CCCCN)C(O)=O.O=C(O)COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C
Biological Activity: Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar lysine shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar lysine can be used for the study of primary biliary cholangitis[1].
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Seladelpar (lysine) | 98.0% | Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar lysine shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar lysine can be used for the study of primary biliary cholangitis. | ||||||||||||||||||||
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Keywords
