Seladelpar (lysine)
Based on 1 publication(s) in Google Scholar
Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar lysine shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar lysine can be used for the study of primary biliary cholangitis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 928821-41-4
- Formel: C27H37F3N2O7S
- Molecular Weight:590.65
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Seladelpar (lysine)
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Biologische Aktivität
Chemical Information
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CAS. Nr. 928821-41-4
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Appearance Solid
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Molecular Weight 590.65
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Formel C27H37F3N2O7S
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Color White to off-white
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SMILES
N[C@@H](CCCCN)C(O)=O.O=C(O)COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C
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Synonyms
MBX-8025 (lysine); RWJ-800025 (lysine)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Drug Metab Dispos
Metabolic flux analysis of bile acid biosynthesis acidic pathway in HepG2 cells reveals CYP8B1 inhibition of azole antifungals. [Abstract]2025 Nov;53(11):100168. PMID: 41124962
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (84.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Bays HE, et al. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97. [Content Brief]
[2]. Haczeyni F, et al. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Hepatol Commun. 2017 Jul 31;1(7):663-674. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6930 mL | 8.4652 mL | 16.9305 mL | 42.3262 mL |
| 5 mM | 0.3386 mL | 1.6930 mL | 3.3861 mL | 8.4652 mL | |
| 10 mM | 0.1693 mL | 0.8465 mL | 1.6930 mL | 4.2326 mL | |
| 15 mM | 0.1129 mL | 0.5643 mL | 1.1287 mL | 2.8217 mL | |
| 20 mM | 0.0847 mL | 0.4233 mL | 0.8465 mL | 2.1163 mL | |
| 25 mM | 0.0677 mL | 0.3386 mL | 0.6772 mL | 1.6930 mL | |
| 30 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.4109 mL | |
| 40 mM | 0.0423 mL | 0.2116 mL | 0.4233 mL | 1.0582 mL | |
| 50 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.8465 mL | |
| 60 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7054 mL | |
| 80 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.5291 mL |
Seladelpar (lysine) Related Classifications
HY-19522B Related Classifications
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