942425-34-5
Chemical Structure
PKN1/2-IN-1
- CAS No.: 942425-34-5
- Formula:C14H15N3O
- Molecular Weight:241.29
IUPAC Name: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide
InChIKey: RVODROMIHSQWCT-UHFFFAOYSA-N
SMILES: CCN1C(C2=CC=NC=C2)=CC3=C1CCNC3=O
Biological Activity: PKN1/2-IN-1 is a potent cell permeabilizer and selective PKN1/2 inhibitor with IC50 values of 16 nM and 210 nM for PKN1 and PKN2, respectively, and Ki values of 8 nM and 108 nM, respectively. PKN1/2-IN-1 exhibits strong intracellular PKN2 binding capacity in NanoBRET assays (IC50 = 2.1 μM). PKN1/2-IN-1 can be used to study physiological processes such as tumor cell migration[1].
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PKN1/2-IN-1 | 99.92% | PKN1/2-IN-1 is a potent cell permeabilizer and selective PKN1/2 inhibitor with IC50 values of 16 nM and 210 nM for PKN1 and PKN2, respectively, and Ki values of 8 nM and 108 nM, respectively. PKN1/2-IN-1 exhibits strong intracellular PKN2 binding capacity in NanoBRET assays (IC50 = 2.1 μM). PKN1/2-IN-1 can be used to study physiological processes such as tumor cell migration. | ||||||||||||||||||||
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Keywords
