94367-42-7
Chemical Structure
Methylnissolin-3-O-glucoside
- CAS No.: 94367-42-7
- Formula:C23H26O10
- Molecular Weight:462.45
IUPAC Name: (2S,3R,4S,5S,6R)-2-(((6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: PCIXSTFFMHVOMF-PBGSHFJYSA-N
SMILES: COC1=C2O[C@]3([H])[C@](COC4=CC(O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO)=CC=C34)([H])C2=CC=C1OC
Biological Activity: Methylnissolin-3-O-glucoside is a flavonoid glycoside derivative of Methylnissolin (HY-N2484). Methylnissolin-3-O-glucoside is isolated from plants of the genus Astragalus (Leguminosae). Methylnissolin-3-O-glucoside effectively induces the expression of AKT/Nrf2 and its downstream target genes HO-1 and NQO1. Methylnissolin-3-O-glucoside inhibits TNF-α-induced phosphorylation of MEK and ERK. Methylnissolin-3-O-glucoside exhibits free radical scavenging activity. Methylnissolin-3-O-glucoside inhibits cell proliferation and cell migration. Methylnissolin-3-O-glucoside is used in research on esophageal squamous cell carcinoma[1][2][3].
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Methylnissolin-3-O-glucoside | 99.84% | Methylnissolin-3-O-glucoside is a flavonoid glycoside derivative of Methylnissolin (HY-N2484). Methylnissolin-3-O-glucoside is isolated from plants of the genus Astragalus (Leguminosae). Methylnissolin-3-O-glucoside effectively induces the expression of AKT/Nrf2 and its downstream target genes HO-1 and NQO1. Methylnissolin-3-O-glucoside inhibits TNF-α-induced phosphorylation of MEK and ERK. Methylnissolin-3-O-glucoside exhibits free radical scavenging activity. Methylnissolin-3-O-glucoside inhibits cell proliferation and cell migration. Methylnissolin-3-O-glucoside is used in research on esophageal squamous cell carcinoma. | ||||||||||||||||||||
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Methylnissolin-3-O-glucoside (Standard) | ≥98% | Methylnissolin-3-O-glucoside (Standard) is the analytical standard of Methylnissolin-3-O-glucoside (HY-N2473). This product is intended for research and analytical applications. Methylnissolin-3-O-glucoside is a flavonoid glycoside derivative of Methylnissolin (HY-N2484). Methylnissolin-3-O-glucoside is isolated from plants of the genus Astragalus (Leguminosae). Methylnissolin-3-O-glucoside effectively induces the expression of AKT/Nrf2 and its downstream target genes HO-1 and NQO1. Methylnissolin-3-O-glucoside inhibits TNF-α-induced phosphorylation of MEK and ERK. Methylnissolin-3-O-glucoside exhibits free radical scavenging activity. Methylnissolin-3-O-glucoside inhibits cell proliferation and cell migration. Methylnissolin-3-O-glucoside is used in research on esophageal squamous cell carcinoma. | ||||||||||||||||||||
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References
- [1]. Lin Z, et al. A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development. Drug design, development and therapy. 2025;19:3763-3777.
- [2]. Lin Z, et al. Sanqi Qushi formula ameliorates renal injury in experimental membranous nephropathy rats by inhibiting the MEK/ERK signaling pathway. Journal of ethnopharmacology. 2025 May 28;348:119813.
- [3]. Qin H, et al. Residue of Chlormequat and Regulatory Effects on the Specialized Metabolites of Astragali Radix. Molecules (Basel, Switzerland). 2023 Sep 22;28(19):6754.
