94936-90-0
Chemical Structure
FK-664
- CAS No.: 94936-90-0
- Formula:C24H29N3O3
- Molecular Weight:407.51
IUPAC Name: (E)-6-(3,4-dimethoxyphenyl)-1-ethyl-4-(mesitylimino)-3-methyl-3,4-dihydropyrimidin-2(1H)-one
InChIKey: OYGHXRNCHYRYRR-YYDJUVGSSA-N
SMILES: O=C1N(C)/C(C=C(N1CC)C2=CC(OC)=C(OC)C=C2)=N/C3=C(C)C=C(C)C=C3C
Biological Activity: FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure[1][2].
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FK-664 | FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure. | |||||||||||||||||||||
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- [1]. Kodama I, et al. Electrophysiological effects of FK664, a new cardiotonic agent, on preparations from guinea pig ventricle and from rabbit sino-atrial node. Cardiovasc Res. 1989 May;23(5):369-77. [Content Brief]
- [2]. Sudo Y,et al. The effect of FK664, a new cardiovascular drug, on systemic capacitance vessels in anesthetized dogs. Life Sci. 1992;51(25):PL261-5. [Content Brief]
Keywords
