959961-23-0
Chemical Structure
AD 01
- CAS 番号: 959961-23-0
- Formula:C115H187N33O42
- Molecular Weight:2703.94
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N3[C@@H](CCC3)C(N[C@@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]4N(CCC4)C([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]5N(CCC5)C([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@@H](N)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner[1][2].
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AD 01 | 99.98% | AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner. | ||||||||||||||||||||
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- [1]. Andrea Valentine, et al. FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin Cancer Res. 2011 Mar 1;17(5):1044-56. [Content Brief]
- [2]. Anita Yakkundi, et al. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 2013;8(2):e55075. [Content Brief]
Keywords
