98206-10-1
98206-10-1
Chemical Structure
Flesinoxan
- CAS No.: 98206-10-1
- Formula:C22H26FN3O4
- Molecular Weight:415.46
IUPAC Name: (R)-4-fluoro-N-(2-(4-(2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)ethyl)benzamide
InChIKey: NYSDRDDQELAVKP-GOSISDBHSA-N
SMILES: O=C(NCCN1CCN(C2=C3OC[C@@H](CO)OC3=CC=C2)CC1)C4=CC=C(F)C=C4
Biological Activity: Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects[1][2][3].
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Flesinoxan | 99.88% | Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects. | ||||||||||||||||||||
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Flesinoxan (Standard) | ≥98% | Flesinoxan (Standard) is the analytical standard of Flesinoxan. This product is intended for research and analytical applications. Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-121653BFlesinoxan hydrochloride -
Similarity Score 0.65
HY-110024AS-14506 -
Similarity Score 0.64
HY-110024S-14506 hydrochloride -
Similarity Score 0.60
HY-180815α1A/1D-Adrenoceptor antagonist-1 -
Similarity Score 0.57
HY-117699Fluanisone -
Similarity Score 0.57
HY-14782Adoprazine -
Similarity Score 0.57
HY-14782AAdoprazine hydrochloride -
Similarity Score 0.57
HY-157563Dopamine D4 receptor ligand 2 -
Similarity Score 0.57
HY-105328S-14489 -
Explore the MedChemAI to find more analogs
References
- [1]. Hadrava V, et al. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 1995 Oct;34(10):1311-26. [Content Brief]
- [2]. Schoeffter P, et al. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975-85. [Content Brief]
- [3]. Rodgers RJ, et al. Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol Biochem Behav. 1994 Aug;48(4):959-63. [Content Brief]
