98537-35-0
Chemical Structure
Neuromedin (B-30)
- CAS No.: 98537-35-0
- Formula:C157H243N51O38S
- Molecular Weight:3484.99
SMILES: O=C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC5=CNC=N5)C(N6[C@@H](CCC6)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CC9=CNC=N9)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Biological Activity: Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord. , and may exhibit activity in stimulating smooth-muscle. Neuromedin B causes local vasodilation, increases vascular permeability and local hyperalgesia, thereby participating in neurogenic inflammation. Neuromedin B regulates appetite, body temperature, and behavioral responses to stress. Neuromedin B is also involved in regulating smooth muscle contraction and secretory function in the gastrointestinal tract[1][2][3].
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Neuromedin (B-30) | Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord. , and may exhibit activity in stimulating smooth-muscle. Neuromedin B causes local vasodilation, increases vascular permeability and local hyperalgesia, thereby participating in neurogenic inflammation. Neuromedin B regulates appetite, body temperature, and behavioral responses to stress. Neuromedin B is also involved in regulating smooth muscle contraction and secretory function in the gastrointestinal tract. | |||||||||||||||||||||
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References
- [1]. Minamino N, et al., Neuromedins: novel smooth-muscle stimulating peptides identified in porcine spinal cord. Peptides. 1985;6 Suppl 3:245-8. [Content Brief]
- [2]. Minamino N, et al., Neuromedin B-32 and B-30: two "big" neuromedin B identified in porcine brain and spinal cord. Biochem Biophys Res Commun. 1985 Jul 31;130(2):685-91. [Content Brief]
- [3]. Mishra SK, et al., A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. [Content Brief]
