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Art. -Nr.: HY-150545

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AChE-IN-21

AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC₅₀ of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro.

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CAS. Nr.: 2413656-04-7
Formel: C₂₄H₂₉NO₄
Molecular Weight:395.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AChE-IN-21 Chemical Structure

CAS. Nr.: 2413656-04-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC₅₀ of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro^[1].

IC₅₀ & Target

EeAChE

2.66 nM (IC₅₀)

RatBuChE

19.10 μM (IC₅₀)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice at body weight of 18–22 g (male and female in half)^[1]
Dosage:

1.0, 5.0 and 25.0 mg/kg
Administration:

Intragastric administration, once a day for 7 consecutive days
Result:

Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.

Related Protocols :

Transepithelial/transendothelial electrical resistance assay

Chemical Information

CAS. Nr. 2413656-04-7
Molecular Weight 395.49
Formel C₂₄H₂₉NO₄
SMILES

O=C1O/C(C2=C1C=C(OC)C(OC)=C2)=C\CCCCCN(CC3=CC=CC=C3)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Luo L, et al. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 15;28(8):115400. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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