ADI-14448
ADI-14448 is a RSV prefusion fusion glycoprotein inhibitor and HMPV fusion glycoprotein inhibitor, with a Kd of 3.8 × 10-10 M for RSV preF. ADI-14448 binds to epitope III of RSV preF, thereby blocking viral infection. ADI-14448 neutralizes RSV subtype A and HMPV subtype A1. ADI-14448 can be used in studies related to respiratory syncytial virus infection and metapneumovirus infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Virus
In Vitro
ADI-14448 binds specifically to pre-fusion RSV F (DS-Cav1) with high affinity, with an apparent Kd of 3.8 × 10-10 M, and does not bind to post-fusion RSV F (F DFP)[1].
ADI-14448 (subjected to serial four-fold dilutions from 1:10 to 1:163,840; pre-incubated with virus for 1 h prior to incubation with HEp-2 cells for 22-24 h) potently neutralizes RSV subtype A (strain A2) in HEp-2 cells, with an IC50 of 0.04 μg/mL[1].
ADI-14448 (serial dilutions; 36 h) potently neutralizes the HMPV A1 sublineage (NL/1/00) in Vero-118 cells, with an IC50 of 0.05 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
/ [NCBI]
Accession
P03420
Target
HRSV F0/F Protein
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Anwendung
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ADI-14448 Related Classifications
HY-P992175 Related Classifications
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Keywords
- ADI-14448
- ADI14448
- ADI 14448
- RSV
- Respiratory syncytial virus
- human RSV preF
- RSV preF antigenic site III
- human HMPV F
- HMPV fusion glycoprotein
- HEp-2 cells
- human metapneumovirus infection
- respiratory syncytial virus infection
- prefusion RSV F (DS-Cav1)
- Vero-118 cells
- RSV prefusion fusion glycoprotein
- Inhibitor
- inhibitor
- inhibit