BGC-20-1531
BGC-20-1531 (PGN 1531), a benzenesulfonamide derivative, is a selective EP4 antagonist. BGC-20-1531 binds to PGE2 enhancing the ATPase activity, which are coupled to Gs proteins and thus activate adenylate cyclase generating cAMP and activating PKA. BGC-20-1531 is promising for research of liver disorders.
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- CAS. Nr.: 1186532-61-5
- Formel: C26H23N2NaO6S
- Molecular Weight:514.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-101952
Prostaglandin E2Prostaglandin Receptor Agonist -
HY-101952R
Prostaglandin E2 (Standard) -
HY-101952G
Prostaglandin E2 (GMP)Inflammatory Mediator (GMP) -
HY-14870
SelexipagProstaglandin Receptor Agonist -
HY-10418
AH 6809EP/DP Antagonist -
HY-108912
RO1138452Prostaglandin Receptor Antagonist -
HY-18971
TG4-155EP2 Receptor Antagonist -
HY-108912R
RO1138452 (Standard)Prostaglandin Receptor Antagonist -
HY-12956A
Dinoprost tromethamine saltFP Receptor Agonist -
HY-14870R
Selexipag (Standard)Prostaglandin Receptor Agonist -
HY-10418R
AH 6809 (Standard)EP/DP Antagonist -
HY-110198
ONO-8130EP1 Receptor Antagonist
Biologische Aktivität
Beschreibung
IC50 & Target
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EP4 |
Chemical Information
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CAS. Nr. 1186532-61-5
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Molecular Weight 514.53
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Formel C26H23N2NaO6S
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SMILES
O=C(C1=CC(COC2=CC=C(C3=NC=C(C=C3)OC)C=C2)=C(C)O1)N([Na])S(=O)(C4=C(C)C=CC=C4)=O
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Synonyms
PGN 1531
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Ammazzalorso A, et al. N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry. Chem Biol Drug Des. 2017 Dec;90(6):1094-1105. [Content Brief]
[2]. Hodeify R, et al. PGE2 upregulates the Na+/K+ ATPase in HepG2 cells via EP4 receptors and intracellular calcium. PLoS One. 2021 Jan 14;16(1):e0245400. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BGC-20-1531 Related Classifications
HY-W394717 Related Classifications
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