Boc-C16-COOH
Based on 1 Customer Validation
Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Non-cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 843666-40-0
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Appearance Solid
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Molecular Weight 370.57
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Formel C22H42O4
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Color White to off-white
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SMILES
CC(C)(OC(CCCCCCCCCCCCCCCCC(O)=O)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (269.85 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.6985 mL | 13.4927 mL | 26.9855 mL | 67.4636 mL |
| 5 mM | 0.5397 mL | 2.6985 mL | 5.3971 mL | 13.4927 mL | |
| 10 mM | 0.2699 mL | 1.3493 mL | 2.6985 mL | 6.7464 mL | |
| 15 mM | 0.1799 mL | 0.8995 mL | 1.7990 mL | 4.4976 mL | |
| 20 mM | 0.1349 mL | 0.6746 mL | 1.3493 mL | 3.3732 mL | |
| 25 mM | 0.1079 mL | 0.5397 mL | 1.0794 mL | 2.6985 mL | |
| 30 mM | 0.0900 mL | 0.4498 mL | 0.8995 mL | 2.2488 mL | |
| 40 mM | 0.0675 mL | 0.3373 mL | 0.6746 mL | 1.6866 mL | |
| 50 mM | 0.0540 mL | 0.2699 mL | 0.5397 mL | 1.3493 mL | |
| 60 mM | 0.0450 mL | 0.2249 mL | 0.4498 mL | 1.1244 mL | |
| 80 mM | 0.0337 mL | 0.1687 mL | 0.3373 mL | 0.8433 mL | |
| 100 mM | 0.0270 mL | 0.1349 mL | 0.2699 mL | 0.6746 mL |
Boc-C16-COOH Related Classifications
HY-W045598 Related Classifications
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